Diego Velasco was featured as one of the 10 Movers and Reshapers of Latin American Cinema by Variety Magazine. His first feature, "La Hora Cero" (The Zero Hour), won multiple festival awards and broke box-office records in his native Venezuela. The Lincoln Center's Film Comment Magazine called it "rare and special: an intelligent, finely constructed and wonderfully acted feature with a subversive message and a sting in the tail."

On the TV front, Velasco directed the memorable immigration episode for Orange is the New Black, which the New Yorker singled out as "brilliant."

Recent TV credits include "Grease, Rise of the Pink Ladies," and This Fool. His episode of "This Fool" ("Sandy Says") was featured as one of the Best TV Episodes of 2022 by The New York Times.

Velasco served as the Producing Director for the second season of "Twenties" (created by Lena Waithe). He was also the Producing Director for "Social Distance", the first scripted anthology to be produced remotely during the COVID pandemic (executive produced by Jenji Kohan).